Thomas Brabletz Selected Research

beta Catenin

3/2015	Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma.
6/2010	Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells.
1/2010	Variable FZD7 expression in colorectal cancers indicates regulation by the tumour microenvironment.
6/2009	E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer.
4/2009	Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells.
1/2009	p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors.
11/2007	Heterogeneous expression of Wnt/beta-catenin target genes within colorectal cancer.
8/2007	Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis.
4/2007	Wnt/beta-catenin signaling in cancer stemness and malignant behavior.
4/2007	Precancerous lesions upon sporadic activation of beta-catenin in mice.

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Thomas Brabletz Research Topics

Disease

56	Neoplasms (Cancer) 12/2021 - 01/2004
36	Colorectal Neoplasms (Colorectal Cancer) 12/2021 - 06/2002
27	Neoplasm Metastasis (Metastasis) 12/2021 - 01/2004
11	Colonic Neoplasms (Colon Cancer) 12/2021 - 12/2004
7	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021 - 12/2004
6	Carcinogenesis 12/2021 - 03/2003
6	Breast Neoplasms (Breast Cancer) 01/2020 - 06/2013
5	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 07/2012 - 07/2002
3	Inflammation (Inflammations) 01/2021 - 11/2007
2	Glioblastoma (Glioblastoma Multiforme) 08/2013 - 12/2012
2	Shock 05/2008 - 07/2005
2	Carcinoma (Carcinomatosis) 08/2007 - 02/2004
2	Adenocarcinoma 09/2006 - 03/2003
2	Adenoma (Adenomas) 02/2005 - 02/2004
2	Microsatellite Instability 01/2004 - 06/2002
1	Type 2 Diabetes Mellitus (MODY) 06/2021
1	Osteosarcoma (Osteogenic Sarcoma) 01/2021
1	Disease Progression 01/2021
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021
1	Splenomegaly 01/2021
1	Osteolysis 02/2017
1	Triple Negative Breast Neoplasms 12/2016
1	Head and Neck Neoplasms (Head and Neck Cancer) 07/2014
1	Herpes Zoster 01/2014

Drug/Important Bio-Agent (IBA)

22	beta CateninIBA 03/2015 - 06/2002
14	Zinc Finger E-box-Binding Homeobox 1IBA 01/2021 - 04/2007
12	Proteins (Proteins, Gene)FDA Link 08/2019 - 03/2003
10	CateninsIBA 12/2021 - 01/2011
9	Cadherins (E-Cadherin)IBA 05/2017 - 04/2007
8	Transcription Factors (Transcription Factor)IBA 06/2021 - 12/2005
4	MicroRNAs (MicroRNA)IBA 01/2021 - 06/2008
4	Biological ProductsIBA 03/2015 - 09/2006
4	VimentinIBA 03/2015 - 01/2011
4	Calcibiotic Root Canal SealerIBA 09/2012 - 02/2005
4	Oncogene Proteins (Oncogene Protein)IBA 01/2007 - 07/2002
3	EnzymesIBA 03/2021 - 01/2017
3	Fibronectins (Fibronectin)IBA 01/2014 - 01/2010
3	TCF Transcription FactorsIBA 06/2010 - 03/2005
3	DNA (Deoxyribonucleic Acid)IBA 08/2007 - 06/2002
2	CollagenIBA 03/2021 - 01/2010
2	Epithelial Cell Adhesion MoleculeIBA 01/2021 - 06/2013
2	Pharmaceutical PreparationsIBA 11/2020 - 01/2014
2	Gemcitabine FDA Link 01/2020 - 12/2004
2	Thymidylate SynthaseIBA 01/2017 - 12/2007
2	Phosphotransferases (Kinase)IBA 12/2016 - 12/2007
2	fascinIBA 01/2016 - 04/2014
2	Small Interfering RNA (siRNA)IBA 09/2015 - 06/2010
2	Metalloproteases (Metalloproteinases)IBA 01/2014 - 02/2005
2	NF-kappa B (NF-kB)IBA 06/2010 - 11/2009
2	RNA (Ribonucleic Acid)IBA 12/2007 - 07/2005
2	Transforming Growth Factor beta (TGF-beta)IBA 09/2006 - 01/2004
1	BiglycanIBA 12/2021
1	SugarsIBA 06/2021
1	gluconic acid (gluconate)FDA LinkGeneric 01/2021
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2021
1	Citric Acid (Citrate)FDA LinkGeneric 01/2021
1	Complementary DNA (cDNA)IBA 01/2021
1	AzoxymethaneIBA 01/2021
1	Dextrans (Dextran)FDA Link 01/2021
1	ClaudinsIBA 01/2020
1	ZincIBA 01/2020
1	IntegrinsIBA 01/2020
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2020
1	JNK Mitogen-Activated Protein KinasesIBA 01/2020
1	Peptide Hydrolases (Proteases)FDA Link 08/2019
1	Aspartic Acid (Aspartate)FDA Link 08/2019
1	Cathepsin DIBA 08/2019
1	Glutamine (L-Glutamine)FDA Link 01/2019
1	Tryptophan (L-Tryptophan)FDA Link 01/2019
1	KynurenineIBA 01/2019
1	Amino Acids FDA Link 01/2019
1	Large Neutral Amino Acid-Transporter 1IBA 01/2019
1	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amideIBA 01/2019
1	Glucose (Dextrose)FDA LinkGeneric 01/2018
1	polyolIBA 01/2018
1	Indicators and Reagents (Reagents)IBA 02/2017
1	Hyaluronic Acid (Hyaluronan)IBA 02/2017
1	Proteoglycans (Proteoglycan)IBA 02/2017
1	Conditioned Culture MediaIBA 02/2017
1	NucleotidesIBA 01/2017
1	staurosporine aglycone (K252a)IBA 12/2016
1	Phenobarbital (Luminal)FDA Link 12/2016
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2016
1	Protein Isoforms (Isoforms)IBA 12/2015
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 09/2015
1	Histone Deacetylase InhibitorsIBA 06/2015
1	mocetinostatIBA 06/2015
1	Keratins (Keratin)IBA 03/2015
1	Etoposide (VP 16)FDA LinkGeneric 04/2014
1	CalpainIBA 04/2014
1	Imatinib Mesylate (Gleevec)FDA Link 04/2014
1	Cisplatin (Platino)FDA LinkGeneric 04/2014
1	Co-Repressor ProteinsIBA 02/2014
1	Temozolomide (Temodar)FDA LinkGeneric 08/2013
1	Telomerase (Telomerase Reverse Transcriptase)IBA 09/2012

Therapy/Procedure

11	Therapeutics 01/2021 - 02/2005
3	Drug Therapy (Chemotherapy) 01/2020 - 01/2014
1	Immunotherapy 11/2020
1	Injections 01/2020
1	Aftercare (After-Treatment) 04/2014